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Neuroprotective Functions for the Histone Deacetylase SIRT6

The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that brain-specific SIRT6-deficient mice survive but prese...

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Principais autores: Shai Kaluski, Miguel Portillo, Antoine Besnard, Daniel Stein, Monica Einav, Lei Zhong, Uwe Ueberham, Thomas Arendt, Raul Mostoslavsky, Amar Sahay, Debra Toiber
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017-03-01
Serier:Cell Reports
Fag:
SIRT6
DNA damage
Tau
Alzheimer’s disease
GSK3
aging
Online adgang:http://www.sciencedirect.com/science/article/pii/S221112471730325X
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