Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

Transcriptional gene silencing (TGS) of mammalian genes can be induced by short interfering RNA (siRNA) targeting promoter regions. We previously reported potent TGS of HIV-1 by siRNA (PromA), which targets tandem NF-κB motifs within the viral 5′LTR. In this study, we screened a siRNA panel with the...

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Autors principals:	Chantelle Ahlenstiel, Catalina Mendez, Steven T H Lim, Katherine Marks, Stuart Turville, David A Cooper, Anthony D Kelleher, Kazuo Suzuki
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-01-01
Col·lecció:	Molecular Therapy: Nucleic Acids
Matèries:	epigenetics heterochromatin histone modifications HIV-1 non-coding RNA si/shRNA transcriptional silencing viral latency
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2162253116300464
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