Reciprocal regulation of hMENA and TGF-β signaling in cancer-associated fibroblasts promotes EMT, immunosuppression, poor prognosis, and ICT resistance in NSCLC

Background Cancer-associated fibroblasts (CAFs) significantly impact cancer progression and CAF subtypes are key determinants of response to immune checkpoint therapy (ICT). The transforming growth factor-β (TGF-β) signaling is a main pathway in protumorigenic activity of CAFs and resistance to ICT....

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Bibliografische Detailangaben

Hauptverfasser:	Paola Nisticò, Isabella Sperduti, Paolo Visca, Lorenzo D’Ambrosio, Francesca Paolini, Annalisa Tocci, Belinda Palermo, Anna Di Carlo, Francesca Di Modugno, Filippo Gallina, Roberta Melchionna, Giulia Campo, Riccardo Tajè, Daniel D’Andrea
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMJ Publishing Group 2026-01-01
Schriftenreihe:	Journal for ImmunoTherapy of Cancer
Online-Zugang:	https://jitc.bmj.com/content/14/1/e013098.full
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