Exosomal hsa-miR-299-3p from endothelium mediates high phosphorus-induced vascular calcification in mice model of CKD via phosphorylated JAK2/STAT5 pathway

IntroductionVascular calcification (VC) is a prevalent and life-threatening complication of chronic kidney disease (CKD), yet the mechanisms by which hyperphosphatemia drives VC remain incompletely understood. This study investigates the role of endothelial cells (ECs)-derived exosomal microRNAs in...

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主要な著者:	Si-Jie Chen, Tao-Tao Tang, Li-Jun Xie, Bo Wang, Yan Di, Min Wu, Zuo-Lin Li, Yi Wen, Lin-Li Lv, Ri-Ning Tang, Bin Wang, Bi-Cheng Liu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-04-01
シリーズ:	Frontiers in Pharmacology
主題:	CKD exosomes hsa-miRNA-299-3p MARCH3 vascular calcification
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1752954/full
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