RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease

Abstract RBM20 is a cardiac splicing regulator whose dysfunction causes severe cardiomyopathies. Here, we uncover an unexpected layer of RBM20 regulation through a previously unrecognized transcription start site located between the canonical exon 1 and exon 2. This alternative transcription start s...

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Autores principales:	Michael H. Radke, Victor Badillo Lisakowski, Stefan Meinke, Thiago Britto-Borges, Valentin Schneider-Lunitz, Oliver Hummel, Sebastiaan van Heesch, Jorge Ruiz Orera, Norbert Hubner, Henk Granzier, Christoph Dieterich, Michael Gotthardt
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-05-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-026-73230-w
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