Influence of pigment epithelium-derived factors on H2O2-induced oxidative damage and melanin synthesis in Melan-a cells

Abstract Background Previous studies have demonstrated that oxidative stress and melanogenesis are regulated by the Wnt/β-catenin signaling pathway. However, the precise mechanism by which the PEDF/Wnt/β-catenin axis modulates apoptosis and melanogenesis remains unclear. Methods Cell viability and m...

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Autores principales:	Yunli Cui, Fuhao Ye, Zengyao Hou, Guohao Li, Luyao Li, Hongxia Zhao, Dongfang Hu, Zhihong Yin, Lingli Chen, Hongmei Ning, Yaming Ge, Quanhai Pang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-12-01
Colección:	Biological Research
Materias:	Melanocytes Oxidative stress Apoptosis Melanin synthesis
Acceso en línea:	https://doi.org/10.1186/s40659-025-00657-8
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