Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy

The deficiency in immunogenicity and the presence of immunosuppression within the tumor microenvironment significantly hindered the efficacy of immunotherapy. Consequently, a nanoformulation containing metal sulfide of FeS and GSDMD plasmid (NPFeS/GD) had been developed to effectively augment antitu...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yingli Luo, Maoyuan Linghu, Xianyu Luo, Dongdong Li, Jilong Wang, Shaojun Peng, Yinchu Ma
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-03-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	PANoptosis Ferroptosis Nanomedicine H2S gas therapy Immunogenic cell death Remodeling immunosuppressive microenvironment
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211383524004714
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