Gpr177 deficiency impairs mammary development and prohibits Wnt-induced tumorigenesis.

Aberrant regulation of the Wnt pathway, essential for various developmental processes, is tightly linked to human breast cancers. By hijacking this evolutionary conserved signaling pathway, cancer cells acquire sustaining proliferation ability, leading to modification of physiologic properties neces...

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Bibliografische Detailangaben

Hauptverfasser:	Eri Ohfuchi Maruyama, H-M Ivy Yu, Ming Jiang, Jiang Fu, Wei Hsu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2013-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	http://europepmc.org/articles/PMC3574013?pdf=render
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