Multimodal classification of mood disorders using structural MRI and polygenic risk scores: a machine learning ablation study in UK Biobank

ObjectiveMood disorder classification from neuroimaging alone remains limited by single-modality constraints and population-level heterogeneity. This study proposes a fusion-based machine learning framework combining structural brain MRI and polygenic risk scores (PRS) derived from genome-wide assoc...

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Autori principali:	Umi Kalsom Mohamad Yusof, Joey Ward, Laura M. Lyall, Rona J. Strawbridge
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Psychiatry
Soggetti:	data fusion major depressive disorder mania/bipolar disorder multimodal machine learning neuroimaging polygenic risk scores
Accesso online:	https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1883424/full
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