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A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation

Abstract Memory formation, fertilization, and cardiac function rely on precise Ca2+ signaling and subsequent Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation. Ca2+ sensitivity of the four CaMKII paralogs in mammals is linked to the length of the variable linker region that undergoes e...

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Auteurs principaux: Bao V. Nguyen, Can Özden, Kairong Dong, Oguz Can Koc, Ana P. Torres-Ocampo, Noelle Dziedzic, Daniel Flaherty, Jian Huang, Saketh Sankara, Nikki Lyn Abromson, Diana R. Tomchick, Rafael A. Fissore, Jianhan Chen, Scott C. Garman, Margaret M. Stratton
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2025-09-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-025-63249-w
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