4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives

A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but also the pharmacological profile. Thus, in order...

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Автори:	Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2022-04-01
Серія:	Pharmaceuticals
Предмети:	G-protein-coupled receptors adenosine receptor ligands aminopyridine-3,5-dicarbonitriles ligand-adenosine receptor modeling studies
Онлайн доступ:	https://www.mdpi.com/1424-8247/15/4/478
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