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Direct Fluoroformylation of the C3‐Position of Indoles with 2,4‐Dinitro(trifluoromethoxy)benzene as Fluorocarbonyl Source

We herein report the direct fluoroformylation of indoles and other heteroaromatic cycles. Acyl fluorides are very useful moieties in coupling reactions with or without metal. However, they are usually obtained from the corresponding carboxylic acids or from aryl halides in pallado‐catalyzed carbonyl...

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Principais autores: Lilian Wisson, Gilles Hanquet, Fabien Toulgoat, Thierry Billard, Frédéric R. Leroux, Armen Panossian
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley-VCH 2026-03-01
coleção:ChemistryOpen
Assuntos:
2,4‐dinitro‐1‐(trifluoromethoxy)benzene
acyl fluoride
fluoroformylation
fluorophosgene
indole
Acesso em linha:https://doi.org/10.1002/open.202500563
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