Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor
Abstract G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still unclear. Using 13C methyl methionine and 19F NMR, we investigate the agonist-bound active state of β1AR and its tern...
Sparad:
| Huvudupphov: | , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Nature Portfolio
2024-02-01
|
| Serie: | Nature Communications |
| Länkar: | https://doi.org/10.1038/s41467-024-45680-7 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|