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Exploration of commercial cyclen-based chelators for mercury-197 m/g incorporation into theranostic radiopharmaceuticals

A comprehensive investigation of the Hg2+ coordination chemistry and 197m/gHg radiolabeling capabilities of cyclen-based commercial chelators, namely, DOTA and DOTAM (aka TCMC), along with their bifunctional counterparts, p-SCN-Bn-DOTA and p-SCN-Bn-TCMC, was conducted to assess the suitability of th...

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Main Authors: Parmissa Randhawa, Imma Carbo-Bague, Patrick R. W. J. Davey, Shaohuang Chen, Helen Merkens, Carlos F. Uribe, Chengcheng Zhang, Marianna Tosato, François Bénard, Valery Radchenko, Caterina F. Ramogida
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Chemistry
Subjects:
radiopharmaceuticals
TCMC
mercury-197
Hg
radiometals
DOTAM
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1292566/full
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