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TNF-α deficiency underlies NK cell dysfunction in colorectal cancer

Natural killer (NK) cells are central to innate antitumor immunity, yet their function is systemically compromised in colorectal cancer (CRC). We show that CRC patients exhibit early and pronounced alterations in peripheral blood NK cells, marked by a reduced frequency of total CD56⁺ cells, a shift...

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Autori principali: Silvia Ruggeri, Beatrice Pizzitola, Mattia Laffranchi, Laura Beltrame, Giuseppe Sciumé, Alessio Grimaldi, Enrico Fiori, Roberto Caronna, Valerio De Peppo, Gian Luca Grazi, Valentina Laquintana, Giulia Turri, Silvano Sozzani, Angela Gismondi, Cinzia Fionda, Angela Santoni, Helena Stabile
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2026-12-01
Serie:OncoImmunology
Soggetti:
NK cells
colorectal cancer
TNF-α
cytokine signalling
Innate Immunity
Accesso online:https://www.tandfonline.com/doi/10.1080/2162402X.2026.2636311
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