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IL-10 Plays a Critical Role in Mitigating Acute Anaemia Development During African Trypanosome Infection

During the first week of <i>T. b. brucei</i> infection, pro-inflammatory IFN-γ production drives acute anaemia by promoting red blood cell clearance by activated macrophages in concert with insufficient bone marrow compensation. The latter is followed by a partial recovery phase, which later progres...

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Principais autores: Maida Živalj, Anaïs St. Martin, Patrick De Baetselier, Liudmyla Maksymova, Fara Berghmans, Louis Boon, Jo A. Van Ginderachter, Stefan Magez, Carl De Trez, Benoit Stijlemans
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-12-01
coleção:Pathogens
Assuntos:
IL-10
erythropoiesis
anaemia
IFN-γ
central macrophage
Acesso em linha:https://www.mdpi.com/2076-0817/14/12/1276
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