Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice

Summary: In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis caused by highly virulent Staphylococcus aureu...

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Detalhes bibliográficos

Principais autores:	Cécile Oury, PhD, Severien Meyers, MSc, Nicolas Jacques, BS, Kirsten Leeten, MSc, Zheshen Jiang, MSc, Lucia Musumeci, PhD, Marleen Lox, BS, Margaux Debuisson, BS, Eric Goffin, PharmD, Bernard Pirotte, PharmD, PhD, Philippe Delvenne, MD, PhD, Alain Nchimi, MD, PhD, Cédric Hubert, PharmD, PhD, Mélanie Heptia, BS, Philippe Hubert, PharmD, PhD, Marijke J.E. Kuijpers, PhD, Thomas Vanassche, MD, PhD, Kimberly Martinod, PhD, Peter Verhamme, MD, PhD, Patrizio Lancellotti, MD, PhD
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-11-01
coleção:	JACC: Basic to Translational Science
Assuntos:	bacterial virulence infective endocarditis Staphylococcus aureus ticagrelor
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452302X2300092X
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