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20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways

Background: Myocardial fibrosis post-myocardial infarction (MI) can induce maladaptive cardiac remodeling as well as heart failure. Although 20(S)-ginsenoside Rg3 (Rg3) has been applied to cardiovascular diseases, its efficacy and specific molecular mechanism in myocardial fibrosis are largely unkno...

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Principais autores: Honglin Xu, Haifeng Miao, Guanghong Chen, Guoyong Zhang, Yue Hua, Yuting Wu, Tong Xu, Xin Han, Changlei Hu, Mingjie Pang, Leyi Tan, Bin Liu, Yingchun Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-11-01
coleção:Journal of Ginseng Research
Assuntos:
CFs proliferation
Collagen deposition
Myocardial fibrosis post myocardial infarction
TGFBR1
20(S)-ginsenoside Rg3
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1226845323000738
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