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Characterization of YKL-40 Binding to Extracellular Matrix Glycosaminoglycans

YKL-40 is a chitinase-like glycoprotein implicated in various pathological processes, yet its glycosaminoglycan (GAG) binding profile beyond heparin has not been examined. In this study, we performed a Microscale Thermophoresis (MST) analysis on the heparin-binding glycoprotein YKL-40 using low mole...

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Principais autores: Unnur Magnusdottir, Yiming Yang Jonatansdottir, Kristinn R. Oskarsson, Jens G. Hjorleifsson, Jon M. Einarsson, Finnbogi R. Thormodsson
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Marine Drugs
Fag:
YKL-40
glycosaminoglycans (GAGs)
extracellular matrix (ECM)
binding affinity
Microscale Thermophoresis (MST)
molecular docking
Online adgang:https://www.mdpi.com/1660-3397/23/10/379
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