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Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOEε4 and mild cognitive impairment

IntroductionAt least one-third of the identified risk alleles from Genome-Wide Association Studies (GWAS) of Alzheimer’s disease (AD) are involved in lipid metabolism, lipid transport, or direct lipid binding. In fact, a common genetic variant (ε4) in a cholesterol and phospholipid transporter, Apol...

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Principais autores: Jason Mares, Ana Paula Costa, William J. Dartora, Krista M. Wartchow, Artur Lazarian, David A. Bennett, Tal Nuriel, Vilas Menon, Laura Beth J. McIntire
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-06-01
Serier:Frontiers in Aging Neuroscience
Fag:
lipidomics
lipid metabolism
Alzheimer’s disease
ROSMAP
ApoE
Online adgang:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1419253/full
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