Development of Quantitative Methylation-Specific Droplet Digital PCR (ddMSP) for Assessment of Natural Tregs

Regulatory T cells (Tregs) suppress immune responses in vivo in an antigen-specific manner. Of clinical relevance, Tregs can be isolated and expanded in vitro while maintaining immunoregulatory function. Tregs are classified as CD4+CD25highCD127low FOXP3+ cells. Demethylation of the Treg-specific de...

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Autori principali:	Mohamed I. Husseiny, Ahmed Fahmy, Weiting Du, Angel Gu, Pablo Garcia, Kevin Ferreri, Fouad Kandeel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-04-01
Serie:	Frontiers in Genetics
Soggetti:	natural T regulatory cells tissue-specific methylation droplet digital PCR methylation-specific PCR/quantitative methylation-specific PCR demethylation of TSDR FOXP3
Accesso online:	https://www.frontiersin.org/article/10.3389/fgene.2020.00300/full
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