Impact of TR₃₄/L98H, TR₄₆/Y121F/T289A and TR₅₃ Alterations in Azole-Resistant <i>Aspergillus fumigatus</i> on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Background: Sterols are the main components of fungal membranes. Inhibiting their biosynthesis is the mode of action of azole antifungal drugs that are widely used to treat fungal disease including aspergillosis. Azole resistance has emerged as a matter of concern but little is known about sterols b...

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Principais autores:	Rose-Anne Lavergne, Marjorie Albassier, Jean-Benoît Hardouin, Carlos Alvarez-Moreno, Fabrice Pagniez, Florent Morio, Patrice Le Pape, Isabelle Ourliac-Garnier
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-01-01
Series:	Microorganisms
Assuntos:	<i>Aspergillus fumigatus</i> sterol ergosterol azole-resistance tandem repeat
Acceso en liña:	https://www.mdpi.com/2076-2607/10/1/104
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