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Depletion of NUAK2 blocks the stemness and angiogenesis and facilitates senescence of lung adenocarcinoma cells via enhancing ferroptosis

Abstract Background NUAK family kinase 2 (NUAK2) has been identified as an important mediator for tumor progression in multiple malignancies. Nevertheless, its role in lung adenocarcinoma (LUAD) remains unclear. Methods Bioinformatic analysis was performed to assess the expression and prognosis of N...

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Principais autores: Jun Fan, Lei Xue, Haoran Lin, Jinhua Luo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-07-01
Serier:Cell Division
Fag:
Lung adenocarcinoma
NUAK2
Ferroptosis
Stemness
Senescence
Online adgang:https://doi.org/10.1186/s13008-024-00128-8
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