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MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway

Abstract Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et al. in Cancer Cell 30:737–749, 2016)....

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Principais autores: Anna Lena Siemund, Thomas Hanewald, Eric Kowarz, Rolf Marschalek
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-04-01
Serier:Cell & Bioscience
Fag:
MLL-r acute leukemia
MLL
AF4
Fusion proteins
pSer domain
SL1
Online adgang:https://doi.org/10.1186/s13578-022-00781-y
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