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Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells

Hydroxyurea (HU) is a ribonucleotide reductase inhibitor widely used for the treatment of sickle cell disease and myeloproliferative disorders, yet a precise nitric oxide (NO) synthase (NOS)-dependent mechanism remains incompletely defined. The role of NOS3 in HU-mediated proliferation, cell cycle,...

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Автори: Teodora Dragojević, Dragoslava Đikić, Slavko Mojsilović, Miloš Lazarević, Dejan Milenković, Olivera Mitrović Ajtić, Emilija Živković, Miloš Diklić, Tijana Subotički, Juan F. Santibanez, Vladan P. Čokić, Milica Vukotić
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2026-03-01
Серія:Antioxidants
Предмети:
hydroxyurea
nitric oxide synthase
replicative stress
proliferation
apoptosis
Онлайн доступ:https://www.mdpi.com/2076-3921/15/4/435
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