MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) is part of a system of signals involved in controlling T-cell activation. Targeting and agonizing GITR in mice promotes antitumor immunity by enhancing the function of effector T cells and inhibiting regulatory T cells. Her...

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Main Authors:	Natalie J. Tigue, Lisa Bamber, John Andrews, Samantha Ireland, James Hair, Edward Carter, Sudharsan Sridharan, Jelena Jovanović, D. Gareth Rees, Jeremy S. Springall, Emilie Solier, Yi-Ming Li, Matthieu Chodorge, David Perez-Martinez, Daniel R. Higazi, Michael Oberst, Maureen Kennedy, Chelsea M. Black, Li Yan, Martin Schwickart, Shaun Maguire, Jennifer A. Cann, Lolke de Haan, Lesley L. Young, Tristan Vaughan, Robert W. Wilkinson, Ross Stewart
Format:	Artigo
Language:	Inglês
Published:	Taylor & Francis Group 2017-03-01
Series:	OncoImmunology
Subjects:	agonist gitr gitrl hexamer medi1873 t cell tumor
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1280645
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