Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding

Recent studies have shown that anti-ERp5 antibodies inhibit platelet activation and thrombus formation; Moreover, ERp5-deficient platelets exhibit enhanced platelet reactivity via regulation of endoplasmic reticulum (ER) stress. In this study, we used a new ERp5-knockout mouse model as well as recom...

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Principais autores:	Kaifei Sun, Yaqiong Zhang, Aizhen Yang, Yuxin Zhang, Zhenzhen Zhao, Xiaofeng Yan, Yi Lu, Yue Han, Depei Wu, Freda Passam, Jingyu Zhang, Yi Wu
Format:	Artigo
Jezik:	Inglês
Izdano:	Taylor & Francis Group 2025-12-01
Serija:	Platelets
Teme:	ERp5 integrin αIIbβ3 platelets redox regulation thrombosis
Online dostop:	https://www.tandfonline.com/doi/10.1080/09537104.2025.2455743
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