Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) was described. Further, new formyl (5a,d-f) and nitro (9a,d-f) coumarin derivatives were synthesized via C-N coupling reaction of various cyclic second...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Essam M. Eliwa, Marcel Frese, Ahmed H. Halawa, Maha M. Soltan, Larissa V. Ponomareva, Jon S. Thorson, Khaled A. Shaaban, Mohamed Shaaban, Ahmed M. El-Agrody, Norbert Sewald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2021-10-01
coleção:	Green Chemistry Letters and Reviews
Assuntos:	coumarin metal-free domino reaction c–n coupling knoevenagel condensation vegfr-2 egfr
Acesso em linha:	http://dx.doi.org/10.1080/17518253.2021.1981462
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!