SGMS2+ macrophages enhance NR4A3hi NK cell infiltration to improve prognosis and PD-1 treatment efficacy in hepatocellular carcinoma

Abstract Backgrounds Hepatocellular carcinoma (HCC) is characterized by an immunosuppressive tumor microenvironment (TME) that critically propels malignant evolution. Sphingomyelin synthase 2 (SGMS2), the pivotal sphingolipid metabolizing enzyme, catalyzes the conversion of ceramide to sphingomyelin...

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Hlavní autoři:	Fansheng Meng, Fulin Nian, Haokang Feng, Zhixue Chen, Qiuyu Jiang, Feng Zhang, Lin Xu, Yueying Chen, Hao Zhang, Tao Ye, Biwei Yang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-11-01
Edice:	Journal of Translational Medicine
Témata:	Macrophage Sphingomyelin synthase 2 Natural killer cell Hepatocellular carcinoma Tumor microenvironment Immune checkpoint inhibitors
On-line přístup:	https://doi.org/10.1186/s12967-025-07040-x
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