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Quantifying capillary transit time distribution: a novel tracer kinetic model accounting for leakiness, back diffusion, and perfusion in MRI and PET imaging—the outflow model

Abstract Background Brain blood perfusion is typically characterized through regional cerebral blood flow metrics. However, recent research demonstrates that the distribution of blood transit times through the capillary network also plays a significant role in physiological processes. Here, we intro...

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Hlavní autoři: Henrik B. W. Larsson, Stig P. Cramer, Edis D. Tireli, Tanne S. W. Larsson, Ulrich Lindberg, Mark B. Vestergaard
Médium: Artigo
Jazyk:Inglês
Vydáno: SpringerOpen 2026-05-01
Edice:EJNMMI Physics
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On-line přístup:https://doi.org/10.1186/s40658-026-00886-0
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