Computational Cardiac Modeling Reveals Mechanisms of Ventricular Arrhythmogenesis in Long QT Syndrome Type 8: CACNA1C R858H Mutation Linked to Ventricular Fibrillation

Functional analysis of the L-type calcium channel has shown that the CACNA1C R858H mutation associated with severe QT interval prolongation may lead to ventricular fibrillation (VF). This study investigated multiple potential mechanisms by which the CACNA1C R858H mutation facilitates and perpetuates...

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Detalhes bibliográficos

Principais autores:	Jieyun Bai, Kuanquan Wang, Yashu Liu, Yacong Li, Cuiping Liang, Gongning Luo, Suyu Dong, Yongfeng Yuan, Henggui Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-10-01
coleção:	Frontiers in Physiology
Assuntos:	CACNA1C mutations L-type calcium channel Long QT syndrome Timothy syndrome ventricular fibrillation dispersion of repolarization
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fphys.2017.00771/full
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