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Stem Cell Bioengineering with Bioportides: Inhibition of Planarian Head Regeneration with Peptide Mimetics of Eyes Absent Proteins

Djeya1 (RKLAFRYRRIKELYNSYR) is a very effective cell penetrating peptide (CPP) that mimics the α5 helix of the highly conserved Eya domain (ED) of eyes absent (Eya) proteins. The objective of this study was to bioengineer analogues of Djeya1 that, following effective translocation into planarian tis...

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Main Authors: Sarah Jones, Bárbara Matos, Sarah Dennison, Margarida Fardilha, John Howl
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
cell penetrating peptide
bioportide
eyes absent protein
neoblast
planarian
confocal microscopy
Online Access:https://www.mdpi.com/1999-4923/15/8/2018
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