Anticonvulsant Potential of 1-Aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines: Insights from Strychnine and Nicotine Models in In Vivo and In Silico Studies

<b>Background:</b> Epilepsy is a chronic, non-communicable brain disorder characterized by recurrent seizures. Some derivatives of 1,2,3,4-tetrahydroisoquinolines have demonstrated anticonvulsant effects. This study aims to investigate the effects of 33 derivatives of 1-aryl-1,2,3,4-tetrahydroisoqui...

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Autors principals:	Azizbek A. Azamatov, Nilufar Z. Mamadalieva, Asmaa A. Mandour, Sherzod N. Zhurakulov, Urkhiya K. Aytmuratova, Valentina I. Vinogradova, Fazliddin S. Jalilov, Firuza M. Tursunkhodzhaeva
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-09-01
Col·lecció:	Pharmaceuticals
Matèries:	1-aryl-1,2,3,4-tetrahydroisoquinoline anticonvulsant seizure nicotine strychnine molecular modeling
Accés en línia:	https://www.mdpi.com/1424-8247/18/9/1350
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