Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage of pre-mRNA splicing. We present two crystal structures of engineered U1 sub-structures, which together reveal at atomic resolution an almost complete network of protein–protein and RNA-protein...

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Egile Nagusiak:	Yasushi Kondo, Chris Oubridge, Anne-Marie M van Roon, Kiyoshi Nagai
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	eLife Sciences Publications Ltd 2015-01-01
Saila:	eLife
Gaiak:	pre-mRNA splicing crystallography spliceosome U1 snRNP 5′ splice site
Sarrera elektronikoa:	https://elifesciences.org/articles/04986
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