Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice

Microglia activity can drive excessive synaptic loss during the prodromal phase of Alzheimer’s disease (AD) and is associated with lowered cyclic adenosine monophosphate (cAMP) due to cAMP phosphodiesterase 4B (PDE4B). This study aimed to investigate whether long-term inhibition of PDE4B by A33 (3 m...

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Egile Nagusiak:	Ben Rombaut, Melissa Schepers, Assia Tiane, Femke Mussen, Lisa Koole, Sofie Kessels, Chloë Trippaers, Ruben Jacobs, Kristiaan Wouters, Emily Willems, Lieve van Veggel, Philippos Koulousakis, Dorien Deluyker, Virginie Bito, Jos Prickaerts, Inez Wens, Bert Brône, Daniel L. A. van den Hove, Tim Vanmierlo
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2024-06-01
Saila:	Cells
Gaiak:	Alzheimer’s disease cyclic nucleotide phosphodiesterases type 4B synapse microglia cognition
Sarrera elektronikoa:	https://www.mdpi.com/2073-4409/13/12/1000
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