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CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets

Abstract De novo assembly of ancient metagenomic datasets is a challenging task. Ultra-short fragment size and characteristic postmortem damage patterns of sequenced ancient DNA molecules leave current tools ill-equipped for ideal assembly. We present CarpeDeam, a novel damage-aware de novo assemble...

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Principais autores: Louis Kraft, Johannes Söding, Martin Steinegger, Annika Jochheim, Peter Wad Sackett, Antonio Fernandez-Guerra, Gabriel Renaud
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-10-01
Serier:Genome Biology
Fag:
Ancient DNA
Metagenomics
De novo assembly
Microbes
Proteins
Online adgang:https://doi.org/10.1186/s13059-025-03839-5
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