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The Transthyretin/Oleuropein Aglycone Complex: A New Tool against TTR Amyloidosis

The release of monomers from the homotetrameric protein transthyretin (TTR) is the first event of a cascade, eventually leading to sporadic or familial TTR amyloidoses. Thus, ligands able to stabilize TTR and inhibit monomer release are subject of intense scrutiny as potential treatments against the...

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Bibliografische Detailangaben
Hauptverfasser: Francesco Bemporad, Manuela Leri, Matteo Ramazzotti, Massimo Stefani, Monica Bucciantini
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-02-01
Schriftenreihe:Pharmaceuticals
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Online-Zugang:https://www.mdpi.com/1424-8247/15/3/277
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