Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

Background: Chronic high-fat diet (HFD) feeding triggers hypothalamic inflammation and systemic metabolic dysfunction associated with endoplasmic reticulum (ER) stress. Glial cells, specifically microglia and astrocytes, are central mediators of hypothalamic inflammation. However, the role of Inosit...

Полное описание

Библиографические подробности

Главные авторы:	L. Stilgenbauer, Q. Chen, D. Pungi, N. James, H. Jayarathne, L. Koshko, S. Scofield, K. Zhang, M. Sadagurski
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-05-01
Серии:	Molecular Metabolism
Предметы:	Hypothalamic inflammation Microglia Hypothalamus ER stress UPR Neuroinflammation
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2212877825000353
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!