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Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas

Abstract Lower grade gliomas frequently harbor mutations in isocitrate dehydrogenase (IDH), which define biologically distinct tumor subtypes. Although IDH-mutant and IDH-wildtype gliomas share similar histological morphology, they display markedly different metabolic profiles that may be exploited...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Shigeo Ohba, Akiyoshi Hirayama, Takao Teranishi, Keisuke Hitachi, Hisateru Yamaguchi, Kazuhiro Murayama, Manabu Natsumeda, Kensuke Tateishi, Kunihiro Tsuchida, Hiroaki Wakimoto, Hideyuki Saya, Russell Pieper, Yuichi Hirose
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2025-11-01
Seri Bilgileri:Acta Neuropathologica Communications
Konular:
Asparagine
Cancer metabolism
Glioma
Glutaminolysis
Isocitrate dehydrogenase
Online Erişim:https://doi.org/10.1186/s40478-025-02193-8
Etiketler: Etiketle
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