Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: A study protocol

Background: It is unclear which laxatives are appropriate to prevent opioid-induced constipation (OIC). This study will evaluate whether prophylactic use of naldemedine prevents OIC in patients with cancer who start opioid administration. Methods: This study is a multicenter, double-blinded, randomi...

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Bibliografske podrobnosti

Principais autores:	Takahiro Higashibata, Jun Hamano, Takaomi Kessoku, Shinya Kajiura, Mami Hirakawa, Yoshiki Horie, Masaki Shimizu, Shunsuke Oyamada, Keisuke Ariyoshi, Kota Kihara, Yohei Yamanaka, Kumi Konishi, Kosuke Doki, Yasuyuki Takashima, Manabu Horiuchi, Masato Homma, Takeshi Yamada, Yoshiyuki Yamamoto, Toshikazu Moriwaki, Tatsuya Morita, Atsushi Nakajima, Hiroka Nagaoka
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2022-10-01
Serija:	Contemporary Clinical Trials Communications
Teme:	Opioid-induced constipation Naldemedine Prevention Randomized controlled trial
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2451865422000849
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