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Structure, gating, and pharmacology of human CaV3.3 channel

T-type calcium channels are implicated in many diseases. Here, multiple structures of CaV3.3 channel elucidate molecular mechanisms of T-type CaV channels activation at low voltage and interaction with different clinically used channel blockers.

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Autori principali: Lingli He, Zhuoya Yu, Ze Geng, Zhuo Huang, Changjiang Zhang, Yanli Dong, Yiwei Gao, Yuhang Wang, Qihao Chen, Le Sun, Xinyue Ma, Bo Huang, Xiaoqun Wang, Yan Zhao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2022-04-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-022-29728-0
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