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ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer

Abstract In metastatic hormone receptor-positive breast cancer, ESR1 mutations are a common cause of acquired resistance to the backbone of therapy, estrogen deprivation by aromatase inhibition. How these mutations affect tumor sensitivity to established and novel therapies are active areas of resea...

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Principais autores: Jamie O. Brett, Laura M. Spring, Aditya Bardia, Seth A. Wander
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-08-01
Serier:Breast Cancer Research
Fag:
Breast cancer
Hormone receptor/estrogen receptor
ESR1 mutation
Resistance
Combination
SERD
Online adgang:https://doi.org/10.1186/s13058-021-01462-3
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