Genes causative of primary immunodeficiency are risk factors for and are over-expressed in systemic lupus erythematosus

BackgroundSystemic lupus erythematosus (SLE) is a polygenic autoimmune disease characterized by the production of autoantibodies leading to widespread inflammation, whereas primary immunodeficiency (PID) disease is a group of specific genetic defects in molecular pathways required for host defense t...

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Principais autores:	Haley Davis, Katherine A. Owen, Adam C. Labonte, Erika L. Hubbard, Sophia Kerns, Jessica Kain, Brian Kegerreis, Prathyusha Bachali, Amrie C. Grammer, Peter E. Lipsky
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Immunology
Assuntos:	autoimmune disease biomarkers genetics lupus machine learning primary immunodeficiency disease
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1494343/full
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