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Targeting RNA-Binding proteins Roquin-1 and Regnase-1 could enhance CAR-iPSC-derived macrophage immunotherapy for solid tumors: a perspective and challenges

Solid tumours present major treatment obstacles because of their immunosuppressive microenvironment and poor response to traditional chimeric antigen receptor (CAR)-based immunotherapies. Recent advances in cellular engineering have introduced CAR-macrophages derived from induced pluripotent stem ce...

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Principais autores: Fatemeh Mirzaei, Andisheh Mosaffa Jahromi, Haniyeh Molavi, Dieter Kabelitz, Kurosh Kalantar, Seppo Meri
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:RNA Biology
Fag:
Solid tumours
CAR-macrophages (CAR-iMacs)
Roquin-1
Regnase-1
immunotherapy
Online adgang:https://www.tandfonline.com/doi/10.1080/15476286.2025.2581385
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