Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

Abstract Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-treated patients to identify genetic loci associated...

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Hlavní autoři:	Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2022-12-01
Edice:	Journal of Translational Medicine
Témata:	Paclitaxel Chemotherapy-induced Peripheral Neuropathy Axon Genome-wide association study
On-line přístup:	https://doi.org/10.1186/s12967-022-03754-4
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