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Enhancing cap-independent translation of linear mRNA

Abstract While cap-dependent translation remains the primary focus in mRNA-based therapeutics, cap-independent translation holds promise for targeting diseases ranging from cancer to neurodegeneration. However, cap-independently translated mRNAs are unstable, produce less protein than capped mRNAs,...

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Autors principals: Sebastian Golojuch, Brendan Largey, Afaf H. El-Sagheer, Tom Brown
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2025-10-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-025-64257-6
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