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LncRNA LEF1-AS1 exerts a carcinogenic effect in breast cancer by accelerating proliferation, metastasis, and epithelial-mesenchymal transition

Abstract Background Breast cancer (BRCA) directly poses a threat to human life safety. This study aims to explore the role of lncRNA LEF1-AS1 in BRCA. Methods Firstly, the levels of LEF1-AS1 in tumor tissues and BRCA cells were detected by qRT-PCR. Furthermore, LEF1-AS1 was inhibited through cell tr...

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Main Authors: Linna Kong, Jiaqi Liu, Huihui Zhang, Jun Chu
Format: Artigo
Language:Inglês
Published: BMC 2025-11-01
Series:Hereditas
Subjects:
Breast cancer
LncRNA
LEF1-AS1
Cancer metastasis
Malignant proliferation
EMT
Online Access:https://doi.org/10.1186/s41065-025-00613-2
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