Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization.
Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is linked to the development of several forms of cancer as well as oncogenic progression like sporadic renal clear-cell carcinomas (RCC). Despite the critical role played by VHL in destruction of hypoxia-inducible factor...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2010-09-01
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| Seria: | PLoS ONE |
| Dostęp online: | http://europepmc.org/articles/PMC2936558?pdf=render |
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