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Revealing the Novel Role of Purinergic Receptor P2X4 in Phagocytic Uptake After Ischemic Stroke

Background Purinergic receptor P2X4 (P2X4R), highly expressed on microglia and macrophages, is activated by ATP released from damaged cells and linked to poststroke inflammation. Previous studies showed that short‐term P2X4R inhibition reduces inflammation and promotes long term recovery, but the me...

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Principais autores: Daylin Gamiotea‐Turro, Chunxia G. Cronin, Sanjeev Kumar Yadav, Arun Kumar Yadawa, Mary‐Katherine Cormier, Bruce T. Liang, Rajkumar Verma
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2024-10-01
coleção:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:
ischemic stroke
macrophages
microglia
P2X4 receptor
phagocytosis
Acesso em linha:https://www.ahajournals.org/doi/10.1161/JAHA.124.037148
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