Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells

Abstract Background Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung cancer (NSCLC), often yield low CTC numbers, hindering comprehensive analys...

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Главные авторы:	Lisa-Marie Rieckmann, Michael Spohn, Lisa Ruff, David Agorku, Lisa Becker, Alina Borchers, Jenny Krause, Roisin O’Reilly, Jurek Hille, Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther, Lena Willnow, Charles D. Imbusch, Peter Iglauer, Ronald Simon, Sören Franzenburg, Hauke Winter, Michael Thomas, Carsten Bokemeyer, Nicola Gagliani, Christian F. Krebs, Martin Sprick, Olaf Hardt, Sabine Riethdorf, Andreas Trumpp, Nikolas H. Stoecklein, Sven Peine, Philipp Rosenstiel, Klaus Pantel, Sonja Loges, Melanie Janning
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-05-01
Серии:	Molecular Cancer
Предметы:	Circulating tumor cells Non-small cell lung cancer Single cell RNA sequencing Intratumor heterogeneity
Online-ссылка:	https://doi.org/10.1186/s12943-024-01984-2
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